HIV ပိုးနဲ႔ေမြးလာခဲ့တဲ့ ကေလးမေလးတေယာက္ ေရာဂါေပ်ာက္

၄-၃-၂ဝ၁၃ အေမရိကန္ျပည္ေထာင္စု၊ မစၥစပိမွ HIV ပိုးနဲ႔ေမြးလာခဲ့တဲ့ ကေလးမေလးတေယာက္ ေရာဂါေပ်ာက္
မစၥစပိမွာ ကေလးမေလးဟာ လြန္ခဲ့တဲ့ ၂ ႏွစ္ေက်ာ္က HIV ပိုးနဲ႔ေမြးလာခဲ့ပါတယ္။ သူ႔ကုိေဆးကုသတာ ေအာင္ျမင္တယ္ဆိုတဲ့ သိပၸံနည္းက် ပဌမဆံုးအေထာက္ထား ေတြ႔လာရပါျပီ။ ဒီ နာမည္မေဖၚတဲ့ ကေလးမကို ေဆးပညာအရ “အလုပ္ျဖစ္ေအာင္ေပ်ာက္သြားျပီ” လို႔သတ္မွတ္ပါတယ္။ တႏွစ္အတြင္းမွာ HIV ကူးစက္ေရာဂါ ဘာလကၡဏာမွ ေပၚမလာပါ။ တကယ္လို႔သာ ဒီကေလးမေလး ဆက္ျပီး က်န္းမာေနမယ္ဆိုရင္ ကမာၻ႔ေဆးပညာသမိုင္းမွာ ဒုတိယလူသားျဖစ္လာပါလိမ့္မယ္။

ဒီေတြ႔ရွိခ်က္ကို အတၲလန္တာမွာရွိတဲ့ ၂ဝဝ၃ ခုႏွစ္ (ရီထရို-ဗိုင္းရပ္စ္) နဲ႔ အခြင့္ေကာင္းယူ ကူးစက္ေရာဂါမ်ား ကြန္ဖရင့္မွာ ထုတ္ေဖၚလိုက္တာျဖစ္ပါတယ္။ (ဘာလ္တီမိုး)၊ ဂြ်န္-ေဟာ့ပကင္း တကၠသိုလ္က ေဒါက္တာ ဒီဘိုရာ ပါေဆာ့ဒ္ ဟာ သုေတသနလုပ္သူေတြထဲက ဦးေဆာင္သူတေယာက္ပါ။

ကေလးမေလးဟာ သူ႔မိခင္က ကိုယ္ဝန္ေဆာင္ေနတံုး HIV ပိုးရွိေနေပမဲ့ ေဆးကုသမႈမယူခဲ့လို႔ HIV ပိုးနဲ႔ေမြးလာခဲ့ပါတယ္။ ကေလးကို မစၥစပိ-တကၠသိုလ္ ေဆးပညာဌာနကို လႊဲလိုက္ျပီး antiretroviral treatment ေဆးစကုိ နာရီ ၃ဝ အတြင္းမွာ ကုသေပးပါတယ္။ ဆရာဝန္ေတြက ထံုးစံမဟုတ္တဲ့ေဆးေပးနည္း သံုးၾကပါတယ္။ (AZT, 3TC, Nevirapine) ေဆး ၃ မ်ိဳး လံုးကိုေပးတာပါ။

ေဆးကုကာစ ကေလးမရဲ႕ HIV viral load ဗိုင္းရပ္စ္ လုဒ္က မ်ားပါတယ္။ တလသမီးမွာ သိသိသာသာနည္းလာတယ္။ တလျပည့္ေတာ့ မရွိေတာ့ပါဘူး။

ဒိေနာက္မွာ ၁၂ လကေန ၁၅ လသမီးအရြယ္အထိ ေဆးဆက္ကုသေပးပါတယ္။

အေၾကာင္းမွလွခ်င္ေတာ့ ကေလးေရာ အေမပါအဆက္အသြယ္မရျဖစ္သြားပါေတာ့တယ္။ ကေလးမ ၂၃ လသမီးမွာ ျပန္ေရာက္လာပါေတာ့တယ္။ အံ့အားသင့္စရာေကာင္းတာက သမီးေလးမွာ viral loads မေတြ႔ေတာ့ပါ။ ဒါေတာင္မွ ေဆးမေပးတာ တႏွစ္ရွိေနပါျပီ။

သိထားဘို႔က ဒီလိုေတြ႔တာ အင္မတန္အားရွိစရာပါ။ ဒါေပမဲ့ တေယာက္သာရွိပါေသးတယ္။ မေအကိုလဲ ဗိုင္းရပ္စ္ အေရအတြက္ ထိန္းထားေနပါတယ္။

ကေလးမေလးအရင္တေယာက္ဟာ “ဘာလင္ကလူနာ” လို႔ေခၚတဲ့ Timothy Brown ျဖစ္ပါတယ္။ ၁၉၉၅ တံုးက သူ႔မွာ ပိုးေတြ႔လို႔ ၁၁ ႏွစ္ၾကာ ေဆးကုတယ္။ ေဆးတန္ခိုးထက္တာေတြ႔ရတယ္။ သူ႔ကို ေဒါက္တာ (ဂ်ီရို ဟတ္တာ) ကေန (လူကီးမီးယား) အတြက္ (စတင္မ္-ဆဲလ္ ထြန္စပလန္႔) လုပ္ေပးခဲ့တယ္။ ဒိေနာက္ (ဘေရာင္း) ကို HIV ေဆးမလိုေတာ့ဘူး။

Mississippi Baby Born With HIV 'Functionally Cured,' Doctors Say
By ANTHONY CASTELLANO
March 4, 2013

A Mississippi baby born with HIV more than two years ago appears to be the first documented case of a child's being cured of the virus, according to doctors and scientists.

The unidentified child has now been "functionally cured" and has been off medication for about a year with no signs of the HIV infection. If the child remains healthy, it would mark only the second time in the world's history that a person has been cured of HIV, which is the virus that causes AIDS.

The landmark case was announced Sunday at the 2013 Conference on Retroviruses and Opportunistic Infections in Atlanta.

Dr. Deborah Persaud of Johns Hopkins University in Baltimore was one of the lead researchers and author of the report, which was released by The Foundation for AIDS Research (amfAR).

The infant was diagnosed with HIV at birth to a mother who did not receive prenatal care or HIV treatment, Dr. Rowena Johnston, director of amfAR, told ABC News.

The infant was transferred to the University of Mississippi Medical Center and started on antiretroviral treatment about 30 hours after birth. Doctors took the apparently unusual step of prescribing three aggressive drugs (AZT, 3TC, nevirapine) at once after birth.

Johnston points to the early intervention of the three medications as the difference-maker.
"If one had to make an educational guess, the difference was receiving the treatment dose very soon after birth, earlier than standard of care in the U.S.," Johnston said.

Initial HIV viral load tests were high and then expectedly decreased in the first month. Viral loads were detectable three times and became undetectable by one month of age.

The baby was on treatment and in care until 12 to 15 months of age, at which point the baby was lost to follow-up after doctors lost contact with the mother and the baby stopped receiving any medication. The baby returned for care at 23 months of age.

Surprisingly, viral loads were still undetectable, despite being off treatment for almost a year.

Johnston said the results were all the more shocking because doctors do not usually recommend stopping treatment at any time in children with HIV from birth.

The results surprised Dr. Hannah Gay, a pediatric HIV specialist at the University of Mississippi, who was treating the child.

"My first thought was to panic. I thought, 'Oh my goodness, I have been treating a child who is not actually infected,'" she said.

A battery of "highly sensitive" tests confirmed the absence of HIV, according to a news release.

Dr. Anthony Fauci, with the National Institutes of Health, cautions that more studies are needed before calling the results a breakthrough.

"You have to be careful because this is just a single case and although the data looked pretty convincing that you got to be careful that this may not be broadly applicable to other situations," Fauci told ABC News Radio.

In Mississippi, Gay gives the child a check-up every few months. "I just check for the virus and keep praying that it stays gone," she told The Associated Press.

The mother's HIV is being controlled with medication and she is "quite excited for her child," Gay added.

The only other documented case of an HIV cure to date remains that of Timothy Brown, the so-called "Berlin patient."
Brown's story -- arguably one of the most followed in the realm of HIV research -- began in 1995 when he was diagnosed with HIV while attending school in Berlin. For the next 11 years, doctors treated him with anti-retroviral therapy, to which he responded positively.

His oncologist, Dr. Gero Hutter of the Charite Hospital in Berlin, opted to give Brown a stem-cell transplant to treat his leukemia. But rather than choosing a matched donor, he used the stem cells of a donor he found who had what is known as a CCR5 mutation, a mutation that makes cells immune to HIV.

After the transplant, Brown was able to stop HIV treatment without experiencing a return of his HIV disease.

The Mississippi case will likely spark new directions of research for adults, too.

"This could prevent a lifetime of treatment," Johnston said. "We want people to understand just how game-changing this may be."

Fauci of the National Institutes of Health says the results could have a global impact if they can be replicated.

"About a thousand babies a day are born HIV infected throughout the world," he said.

http://abcnews.go.com/Health/mississippi-baby-born-hiv-functionally-cured-doctors/story?id=18645410

Researchers: Toddler cured of HIV
By Saundra Young, CNN
March 4, 2013 -- Updated 2154 GMT (0554 HKT)
< http://edition.cnn.com/2013/03/03/health/hiv-toddler-cured/index.html